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The latex irradiated with the primary dose of 100 or 200 kGy was used to prepare NR films.
Its primary dose limiting toxicity has been bone marrow suppression; other side effects include nausea, vomiting and fatigue.
A booster dose administered 6 to 12 months after the primary dose is recommended to extend protection.
Participants who received all 3 primary doses as DTaP-Hib had antibody concentrations 2-4 years later that were approximately half those of participants who received all 3 primary doses as DTwP-Hib.