Proaggregation and procoagulant activity, increased platelet Acceleration of thrombin production, overproduction of tissue Factor, and other procoagulant factors
Cytokine production by tumor cells, production of TNF-1, interleukin-11, and VEGF Direct interactions between tumor cells and the endothelium of blood vessels (increased adhesiveness) Factors related to cancer treatment--surgery, radiotherapy, chemotherapy, and antiangiogenic treatment Increased immobilization, central venous catheters TABLE 2: Patient population description.
Our results suggest that after hepatic resection there is a marked increase in procoagulant factors
. However, there may also be reductions in the levels of circulating natural anticoagulants.
Furthermore, all markers for vasculitis and procoagulant factors
were negative, homocysteine levels were normal, MRA examination were normal.
(4-6) Women with familial coagulation disorders, including factor V Leiden mutation, prothrombin G20210A mutation, deficiencies of anticoagulant proteins (antithrombin, protein C, protein S), and elevations in procoagulant factors
(factor VIII, factor IX, factor XI), are 2 to 8 times more likely to experience a VTE event than are unaffected individuals.
As mechanistic studies have progressed, the pathophysiologic mechanism for thrombosis with many of the acquired risk factors has been associated with perturbations in procoagulant factors
, the vasculature, or blood flow.
Circulating estrogens induce the hepatic production of procoagulant factors
VII, VIII, IX, and X.
Rosendaal, "Procoagulant factors
and the risk of myocardial infarction in young women," European Journal of Haematology, vol.