Identification of quantitative trait
loci for production traits in commercial pig populations.
The greatest success story for alcohol-related QTL mapping in rodents has been the discovery of a quantitative trait
gene (QTG) (9) that affects acute withdrawal severity from both alcohol and pentobarbital in mice.
Genetic mapping of quantitative trait
loci for growth and fatness in pigs.
Accordingly, the search for trans eQTLs may allow researchers to identify biological functions associated with complex traits through defining quantitative trait
gene networks (QTGNs).
Armed with several powerful new bioinformatic and biostatistical tools being developed specifically to take full advantage of the resource, the CC will enable researchers to hunt far more precisely and efficiently for the multiple genes and quantitative trait
loci that constitute complex traits, and will allow the community to share and integrate their raw data sets far more effectively.
2011) identified quantitative trait
loci for fertility and milk production on BTA12.
loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout (Oncorhynchusmykiss).
For example, researchers have used such models to detect and map quantitative trait
loci (QTLs)--chromosomal regions containing or linked to the genes that underlie a quantitative, complex trait.
Buckler, Holland, McMullen, Flint-Garcia and others are using the NAM lines to search for quantitative trait
loci (QTLs) and other signposts along the corn genome that can be linked to desirable qualities and traits.
Among their topics are combining information across genome-wide linkage scans, heterogeneity in the meta-analysis of quantitative trait
linkage studies, an approach to composite hypothesis testing built on intersection-union tests and Bayesian posterior probabilities, significance testing for small microarray experiments, combining genomic data in human studies, and a misclassification model for inferring transcriptional regulatory networks.
KEY WORDS: Genetic theory of alcohol and other drug use; genetic factors; environmental factors; behavioral phenotype; behavioral trait; quantitative trait
gene (QTG); inbred animal strains; recombinant inbred (RI) mouse strains; quantitative traits
; quantitative trait
locus (QTL) mapping; multiple cross mapping (MCM); heterogeneous stock (HS) mapping; microsatellite mapping; animal models
The University recently developed the first porcine radiation hybrid map, in collaboration with the Institut National de la Recherche Agronomique, France, and will provide AniGenics with second-generation quantitative trait
maps for swine.