Tumor targeting with antibody-functionalized, radiolabeled
Key words: ant-mediated dispersal; dispersal distances; genetic structure; mating system; outcrossing rate, radiolabeled
seeds; seed dispersal; self-incompatibility; Trillium grandiflorum.
The expected radiolabeled
products of a mild oxidation of [[sup.3]H]sucrose would be the sucrose and [sup.3][H.sub.2]O, because sucrose, a nonreducing sugar, is much less susceptible to oxidation compared with its hydrolysis products, glucose and fructose (Jeanes and Isbell, 1941).
Corrected DPM soma = [(DPM soma - DPM paired control soma)/male radiolabel
concentration] [multiplied by] 100.
Such high blood protein binding of the radiolabeled
drug might help to retain the radiopharmaceutical in blood and cause less pharmacological change in the body .
However, more complex formulations may be required to ensure that the radiolabeled
IMP is representative of the unlabeled version, e.g.
Shahid, "Antimicrobial peptides as infection imaging agents: better than radiolabeled
antibiotics," International Journal of Peptides, vol.
First, increased vascular permeability associated with inflammation can be exploited by injecting radiolabeled
molecules that will show high levels of uptake at sites of infection.
The data for partition coefficient of the radiolabeled
drug are shown in the Table-3.
The densitometry was used to quantify the amounts of radiolabel
incorporated into each band with respect to the total amount of radiolabel
in protein in each sample [ILLUSTRATION FOR FIGURE 3 OMITTED].
Y-mAbs earlier stage efforts, particularly radiolabeled
Lu177-omburtamab, "could provide significant upside as it progresses through the clinic to treat B7-H3 positive CNS/LM (central nervous system / leptomeningeal metastasis) tumors in adults," Nierengarten wrote.
Under the agreement ITM receives an option for a worldwide exclusive license for clinical development and commercialisation of radiolabeled
folate derivatives, while Merck KGaA will supply folate precursors for radiolabeling.