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It can lead to an extensive rearrangement of the gel network.
Subtelomeric rearrangements and several other well-known syndromes are not visible with normal- or high-resolution chromosomal analysis.
SopE requires the type III-secretion system to be translocated into the host cell, where it can directly stimulate actin cytoskeletal rearrangements. It acts as a guanidine exchange factor for members of the Rho subfamily of small GTPases.
A series of experiments revealed no significant influence of the presence of low levels of pigments on the layer rearrangement. Note that the layers are very uniform in thickness, producing a fiat interface.
Southern blot hybridization was one of the first molecular pathology tests to be largely used, as well as the reference method for detecting bcr gene rearrangements. With the advent of the polymerase chain reaction (PCR), however, procedures to detect bcr gene rearrangements at the mRNA level have proved highly superior in terms of sensitivity.
Eighteen individuals collected from throughout the hybrid zone and heterozygous for up to three fission rearrangements (table 1), were chosen for meiotic analyses.
This is because the BCR-ABL fusion gene can also result from variant and complex translocations and from cryptic chromosomal rearrangements.10 Proposed mechanisms of these atypical gene rearrangements, though not fully characterized, involve a cryptic insertion between or submicroscopic deletions of chromosomes 9 and 22 or a classic t (9:22) followed sequentially by a reverse translocation.
'As an increasing and diverse number of tumour genome sequences become available, we may be able to define further rearrangement processes that underlie fusion genes and thus unravel the causes of fusion-driven human cancers,' noted David Malkin, co-leader author, Oncologist, at the SickKids Hospital.
In our study, we evaluated the rate of rearrangements of the genes BRCA1 and BRCA2 in 1809 patients at high risk for breast and ovarian carcinoma, as the current rearrangement rate is not known in the Turkish population.
Fisher, "The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review," Histopathology, vol.
Zhu et al., "ALK, ROS1 and RET rearrangements in lung squamous cell carcinoma are very rare," Lung Cancer, vol.