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The main goal is not only induction of insulin biosynthesis, but also its correct processing, storage and regulated secretion in response to physiologic signals, without which such cell-therapy approaches would not be significantly advantageous over insulin administration," he adds.
The data on biosynthesis and regulated secretion combined with earlier findings of a family of highly conserved and specific receptors and multiple downstream signaling events point to the endogenous CGs as new mammalian hormones (14).
The brain is the only source of the regulated secretion of vasopressin.

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