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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
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Interestingly, the lack of a severe neurological phenotype in patients with homozygous/compound heterozygous regulatory mutations has been recently reported for another congenital disease, polycystic kidney disease with hyperinsulinemic hypoglycemia (HIPKD) (17).
Evidence for both a regulatory mutation and a structural mutation in a family with maple syrup urine disease.
They eliminated the possibility that this association is due to the presence of strong linkage disequilibrium with an unknown regulatory mutation by demonstrating that there is no difference in relative TYRP1 expression between color morphs.

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