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DKC is a disease of defective telomere maintenance, and patients with DKC have premature telomere shortening and subsequent replicative senescence, leading to premature stem cell failure, aging, and cancer predisposition.
dependent deacetylases with epigenetic modulation activity, can prevent vascular endothelial replicative senescence by increasing antioxidant defense [109, 110].
We used PCR to measure relative TL at PD upon replicative senescence (46 PD) and acrolein-induced senescence (30 PD) in HFL-1 cells and the equivalent PD (30 PD) in vehicle (sterile water) control HFL-1 cells.
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
5,7,11 Fibroblasts isolated from WS patients exhibit genomic instability, increased sensitivity to specific DNA damaging agents, slow proliferation, lengthened S-phase, and accelerated replicative senescence.
beta]-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures.
Other gene products are thought to influence replicative senescence.
At "physiological" concentrations, reactive oxygen species (ROS) may play adaptive roles as signalling molecules involved in gene regulation, cell growth, differentiation, replicative senescence and apoptosis (cell death), and as a primary defence invoked by white blood cells against invading organisms.
Astonishingly, many of the genes responsible for replicative senescence in eukaryotes (such as paramecia and yeast) that emerged a billion or more years ago are still present in human beings today.
Furthermore, this replicative senescence also compromises their immunomodulatory and differentiation functions and possibly their clinical activity against GVHD and other inflammatory pathologies [42,43].
However, to date there is no evidence that replicative senescence plays a physiologically significant role in normal aging or age-related disorders.