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In many studies, it has been reported that opiates must be avoided because patients with JS have abnormalities in respiratory control resulting in episodic tachypnea and apnea and a susceptibility to the respiratory depressant effects of anesthetic agents (3, 4).
Moscicki, "Analgesic and respiratory depressant activity of nalbuphine: a comparision with morphine", Anesthesiology, vol 57, no.
Because of that, methadone's peak respiratory depressant effects "typically occur later and persist longer than its peak analgesic effects," according to the FDA.
It also advised against prescribing Phenergan with other drugs that have a respiratory depressant effect.

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