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Related to reticular activating system: reticular formation
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A strong functional component of the drive to breathe in wakefulness, referred to as the wakefulness drive, might reside within the reticular activating system of the forebrain.
The prevailing finding is that the activity of groups of inhibitory neurons located in the frontal cortex of the brain are depressed and are unable to inhibit or control information from lower brain structures, most notably the limbic structures that mediate emotion and the reticular activating system that controls arousal (Quinn, 1995).
Typically, these hypotheses propose the involvement of cortical (frontal) and subcortical structures (brain stem reticular activating system, thalamus, hypothalamus, and basal ganglia).