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Over time it has been discovered that the administration of a much lower dose of rHuEpo over a longer period of time masks the reticulocyte response.
A pronounced reticulocyte response was observed following each dose of Hematide, and at least 50 percent of patients in both dose groups had hemoglobin increases greater than or equal to 1 g/dL by week 7, which appeared to be sustained through week 13.
The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin.