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Related to retrograde transport: Axoplasmic flow, anterograde transport
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Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2treated cells.
We found that nocodazole completely blocked LTF at distal synapses, indicating an essential role for active anterograde and/or retrograde transport in LTF at distal synapses.
The peptide antigen is then directed via retrograde transport into the antigen-processing pathway of these cells, where it is metabolized and presented on the cell surface in a way which activates the immune system.