Yonaths willpower was tested when she did her research, especially when she insisted that she could unlock the secrets of the ribosome
5) Long regarded as simply tiny protein-manufacturing plants, ribosomes
are now emerging as essential in the maintenance of normal cellular functions, and as key players in the science of "systemic aging" and disorders such as chronic fatigue syndrome.
No synonymous SNPs in the rrs gene result in reduced amino glycoside binding while allowing for preserved ribosome
The cytoplasm appeared electron-dense and contained numerous ribosomes
Modeling a minimal ribosome
based on comparative sequence analysis.
mRNA moves out of the nucleus of the cell to a free ribosome
in the cytoplasm to begin the process of protein synthesis.
then convert the mRNA instructions into proteins.
In our case, the work relating to ribosome
is finding applications within ten years after the discovery of its structure," the physicist- turned- biologist said, when asked about the practical utility of fundamental work in science.
Ada E Yonath, who shared the 2009 chemistry prize with V Ramakrishnan for discovering ribosome
's translation of DNA information into life, also a major target for new antibiotics in medicine, showed it was looking at the hibernating bears and how they packed their ribosomes
before preparing for the harsh winter that she got an insight into how this molecular machine existed beyond environmental conditions.
Separation of ribosome
classes in eggs, embryos, and larvae
She was awarded the prize for ribosome
research, which is used to develop new antibiotics.
The Laureates also created three-dimensional models that show how different antibiotics bind to the ribosome
, research that has been applied to develop new anti-infective medicines.