In this study, researchers again used structure-based design to map and re-engineer how spectinomycin binds to the ribosomes
of clinically important bacteria with a focus on generating compounds that work on a broader spectrum of disease-causing bacteria.
The code signals could get destroyed, or it could be part of a test to see whether the ribosome
is working properly.
5) Located in nearly every cell in the body, ribosomes
are the sites of protein production and are intimately involved in the function of every tissue, organ, and system.
The rpsL gene encodes the 12S protein, which is a structural component of the ribosome
The cytoplasm appeared electron-dense and contained numerous ribosomes
Modeling a minimal ribosome
based on comparative sequence analysis.
mRNA moves out of the nucleus of the cell to a free ribosome
in the cytoplasm to begin the process of protein synthesis.
then convert the mRNA instructions into proteins.
In our case, the work relating to ribosome
is finding applications within ten years after the discovery of its structure," the physicist- turned- biologist said, when asked about the practical utility of fundamental work in science.
STOCKHOLM: Three scientists who produced atom-by-atom maps of the mysterious, life-giving ribosome
won the Nobel Prize for Chemistry on Wednesday, a breakthrough that has been vital for the development of new antibiotics.
Ada Yonath was awarded the 2009 Nobel Prize in chemistry on Wednesday for "studies of the structure of the ribosome
Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ribosome