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The landmark JUPITER study (The Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) provides an example of how a novel cardiovascular risk marker can function.
Plasma N-terminal pro-brain natriuretic peptide as a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria.
Only a small proportion of the deaths in this category are defined by high risk markers such as low ejection fraction and ventricular arrhythmias.
As noted recently in a scientific statement by the American Heart Association (AHA) (7), risk markers should demonstrate independence in multiple prospective cohort studies, must demonstrate incremental information beyond usual risk factors (i.
High Accuracy of the Natriuretic Peptide (NP)-based Test Segment to Result in Greater Demand for Cardiac Risk Markers
We have shown that individuals who have above-average levels of a protein called SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels," Anders Rosengren, a researcher at the Lund University Diabetes Centre (LUDC), who led the work on the risk marker, said.
For a new risk marker to be considered as useful for risk prediction, it must be shown to be a statistically independent predictor after an accounting for established risk factors.
Although the shift in the area under these ROC curves suggests BNP or NTproBNP maybe a valuable risk marker in patients with existing CVD (and perhaps in the lower-risk populations as well), only 2 studies reported measures of calibration or reclassification.
Importantly, a statistical analysis suggested that the increases in adiponectin observed in the trial were beyond the anticipated improvements, which could be attributed to weight loss alone, raising the potential of a direct effect of rimonabant on this risk marker.
The strong connection also means it is appropriate to use neurotensin as a clinical risk marker for the conditions, in the view of the researchers.
A substantial body of evidence published in peer-reviewed journals, including more than 25 prospective population-based studies, supports Lp-PLA2 as a cardiovascular risk marker that provides new information, over and above traditional risk factors, to help uncover hidden heart attack and stroke risk.
The gene can be used as a risk marker for fractures and opens up opportunities for preventive medicine against fractures.

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