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The four-parameter saturation kinetics model has several advantages: (a) being extremely robust (b) analyzing all data points even if it is hyperbolic in nature (c) makes no assumption that urinary iodine excretion by humans is constant and (d) facilitates the actual calculation of parameters from the data observed and the determination of required levels of nutrient intake to prevent deficiency.
Phenytoin toxicity may occur earlier than this because of its zero-order, saturation kinetics, which progressively increases the time required for 50% elimination as the level rises.
When exposed to a range of NaCl concentrations, both PWA and SD animals displayed saturation kinetics.