scissile


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Similar to Endo IV, the pro-Rp rather than the pro-Sp nonbridging oxygen of the scissile phosphate is intolerant of thio-replacement.
Two conserved His residues surrounding the scissile phosphate haven shown to be important for the general acid-and-base catalysis, and the His mutations can be rescued by imidazole.
In the proposed mechanism for sedolisin, Glu80 acts as a general base to accept a proton from Ser287 during the nucleophilic attack and then as a general acid to protonate the leaving group during the cleavage of the scissile bond.
The two companies will evaluate the combination of IDB's Scissile Linkage Technology (SLT) and Cycling Probe Technology (CPT) with Nanogen's Automated Programmable Electronic Matrix (APEX) technology for use in microchip formatted diagnostics.
IDV's parent, ID Biomedical, is a Canadian biotechnology company which is developing a nucleic acid diagnostic system and related products based on its proprietary Scissile Linkage Technology and Cycling Probe Technology.
The companies will evaluate the use of IDB's proprietary Scissile Linkage Technology (SLT) and Cycling Probe Technology (CPT) for human in-vitro diagnostics.
Hitachi is evaluating IDB's proprietary Scissile Linkage Technology (SLT) and Cycling Probe Technology (CPT) for the detection of single base mutations of genetic sequences.
The companies will investigate the use of IDB's proprietary Scissile Linkage Technology (SLT) and Cycling Probe Technology (CPT) for the diagnosis of Human Papilloma Virus and the adaptation of IDB's technology to Beckman's instrument systems.