References in periodicals archive ?
Mice transgenic for the Ig H chain 3H9 and its variants established by Weigert and colleagues are useful in analyzing the self-tolerance of B cells producing anti-nuclear autoantibodies, because these Ig H chains generate anti-nuclear antibodies by associating with various Ig L chains.
Breakdown of self-tolerance and the pathogenesis of autoimmunity.
Severe thrombocytopenia often develops in dogs as an autoimmune process, in which the immune system loses self-tolerance and destroys platelets as if they were foreign invaders.
There is accumulating evidence that naturally arising CD4+CD25+regulatory T (Treg) cells play a crucial role in the maintenance of immunologic self-tolerance and negative control of immune responses [8].