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Inotrem is currently conducting a clinical Phase 2 trial investigating the benefit of its lead compound, Motrem (LR12), in patients with septic shock.
Sepsis and septic shock are major health problems with high morbidity and mortality that affect millions of people across the globe each year.
Results from the multi-center study showed that patients with a decrease in PCT less than or equal to 80 percent during the first four days following diagnosis of severe sepsis or septic shock had a two-fold increased risk of death as compared to those who experienced a decrease in PCT greater than 80 percent.
Statistical analysis showed that patients with severe acute respiratory distress syndrome (ARDS), septic shock, history of chronic liver disease and human immunodeficiency virus (HIV) neutropenic sepsis and those who received invasive mechanical ventilation were at higher risk of mortality.
Methods: Ninety emergency patients with septic shock were divided into a treatment group and a control group by random draw.
The EMA's decision to include MOTREM in the PRIME scheme was supported by data from a Phase 1 clinical trial showing tolerance, preclinical models demonstrating efficacy, and the fact that there is an important and unmet medical need for the treatment of septic shock.
Septic shock is defined as severe sepsis accompanied by hypotension that does not respond adequately to fluid replacement.
9, predicting a mortality of greater than 80%CytoSorb treatment was initiated after standard therapy failed to treat septic shock (mean 7.
Septic shock symptoms include: Feeling dizzy or faint A change in mental state - such as confusion or disorientation Diarrhoea Nausea and vomiting Slurred speech Severe muscle pain Severe breathlessness Less urine production than normal - for example, not urinating for a day Cold, clammy and pale or mottled skin Loss of consciousness Can it be cured?
Chronic comorbidities, which included CVD, arrhythmias, hypertension, congestive heart failure, hyperlipidemia, and DM, were seen more frequently in patients with cardiogenic and septic shock.
The Surviving Sepsis guidelines additionally stress the importance of initiating antibiotics within an hour of identification of septic shock, with empiric therapy targeted to the suspected site of infection and responsible organisms, and then working to obtain infection source control as quickly as possible24.
The Elecsys BRAHMS PCT assay can aid in assessing the risk of critically ill patients to progress from severe sepsis to septic shock and help determine the 28-day mortality risk in sepsis patients.