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In hereditary persistence of foetal haemoglobin (HPFH), HbF exists at high levels in all red cells so all red cells are equally protected from sickling.
In this study, antenatal sickling complications were 72% in SCD compared to only 7% in SCT.
Erythrocyte sickling during exercise and thermal stress.
The recommendation by the group that the sickling test be the preferred and sole method for screening, purely on the basis of economics, is disconcerting, while with its observed shortcomings the proposed screening method would be of short-term benefit.
In the event of a sickling collapse, athletic department staff, coaches, and medical staff should treat it as a medical emergency by doing the following: call 911; check vital signs; administer high-flow oxygen with a non-rebreather face mask; cool the athlete, if necessary; and tell the doctors to expect explosive rhabdomyolysis and grave metabolic complications.
Fetal hemoglobin (Hb F) does not participate in sickle hemoglobin polymerization and therefore reduces the sickling in the red blood cell.
Blood flow in the joint was drastically slowed down, causing sickling and vessel blockages leading to bone infarction.
Potassium, lost from cells during sickling, may be replaced with IV or PO potassium supplements (Huff, 1989; Martinelli, 1991 Wayne, Kevy, & Nathan, 1993).
Because the gene for sickling disease is recessive, a child must inherit it from both parents in order to develop the full-blown illness.
Baehner RL, Provisor AJ: Bacterial infections in sickling disorders, in Schwartz E (ed): Hemoglobinopathies in children.