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The most common diagnoses related to obstructive patterns include COPD, asthma, bronchitis, cystic fibrosis, and small airways disease, Dr.
Although diseases frequently involve the small airways, the concept of small airways disease is one of which many pathologists lack a strong understanding.
For example, the FEF25-75% helps distinguish healthy smokers from healthy nonsmokers in large groups of individuals; this suggests it could be an early marker of small airways disease.
Small airways disease, subdivided into mineral dust-associated small airways disease (11) and smoking-related small airways disease (12,13), was identified, and exposure to cigarette smoke in the recent past was assessed on the basis of accumulation of characteristic smokers' macrophages within the respiratory bronchioles and adjacent alveoli (14,15).

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