Lung biopsy shows non-necrotizing epithelioid granulomas (Figure 1C) and small airways disease
The most common diagnoses related to obstructive patterns include COPD, asthma, bronchitis, cystic fibrosis, and small airways disease
COPD is a slowly developing progressive small airways disease
comprised broadly of chronic bronchitis and emphysema, and characterized by airflow limitation and decreased lung function.
Although diseases frequently involve the small airways, the concept of small airways disease
is one of which many pathologists lack a strong understanding.
For example, the FEF25-75% helps distinguish healthy smokers from healthy nonsmokers in large groups of individuals; this suggests it could be an early marker of small airways disease
Small airways disease
, subdivided into mineral dust-associated small airways disease
(11) and smoking-related small airways disease
(12,13), was identified, and exposure to cigarette smoke in the recent past was assessed on the basis of accumulation of characteristic smokers' macrophages within the respiratory bronchioles and adjacent alveoli (14,15).
THORACIC HRCT: Findings and Approach - Part 1 & 2 Idiopathic Interstitial Pneumonias:Stirring the Alphabet Soup Small Airways Disease
Coronary CTA Brett M.