Denovo expression of glutamine synthetase during transformation of hepatic
stellate cells into myofibroblast-like cells.
Dennison, "Pancreatic
stellate cells and pancreas cancer: current perspectives and future strategies," European Journal of Cancer, vol.
During this pathological process, hepatic
stellate cells (HSCs) are the main executor of fibrogenesis.
Prolonged exposure to these harmful factors causes hepatocyte apoptosis, inflammatory cell recruitment, endothelial cell impairment, and, lastly, activation of hepatic
stellate cells, the major cells involved in liver fibrosis.
Friedman, "Hepatic
stellate cells: protean, multifunctional, and enigmatic cells of the liver," Physiological Reviews, vol.
Immortalized hepatic
stellate cells, LX-2, were cultured using the method stated in previous study by Rahmaniah et al.
(1) Analysis of tryptic digests of this protein resulted in its identification as "
stellate cell activation-associated protein" (STAP) by quadrupole-time-of-flight mass spectroscopy and determination of two amino acid sequences: PGDME(I/L)ER and ANCEDVGVA.
Hepatic and pancreatic
stellate cells (HSCs and PSCs) have been considered to be closely associated with the pathogenesis of fibrosis, offering a hopeful therapeutic target for treating hepatic and pancreatic fibrosis.
Keywords: Aqueous extract, hepatic
stellate cells, Masson pine pollen.
Hepatic
stellate cells treated with capsaicin showed decreased lipid accumulation in dose- and time-dependent manners (Bitencourt et al., 2012).
A small study in HCV patients with 1200 IU alpha-tocopherol for 8 weeks resulted in blockage of the pathway for
stellate cell activation, preventing steatosis and fibrosis progression and an improvement in liver biopsy.
LX2 is an immortalized human hepatic
stellate cell line and these cells are fully activated (Xu et al.