Aberrant expression of stem cell factor
on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis.
They were thus able to conclude that mast cell progenitors did not require stem cell factor
LIF: leukemia inhibitory factor; SCF: stem cell factor
; SDF-1: stromal cell-derived factor; BMP-4: bone morphogenetic protein 4; FLT-3: HSC-stimulating factor; TGF-[beta]: transforming growth factor-[beta]; IFN-[gamma]: interferon-[gamma]; TNF-[alpha]: tumor necrosis factor-[alpha]; B7-H1: programmed death ligand.
Kodera, "Plasma levels and production of soluble stem cell factor
by marrow stromal cells in patients with aplastic anaemia," British Journal of Haematology, vol.
Nonhematopoietic tumor cell lines express stem cell factor
and display c-kit receptors.
Jiang et al., "Hypoxia-induced astrocytes promote the migration of neural progenitor cells via vascular endothelial factor, stem cell factor
, stromal-derived factor-1alpha and monocyte chemoattractant protein-1 upregulation in vitro," Clinical and Experimental Pharmacology & Physiology, vol.
The result is a soluble cell conditioned media containing cell-signaling proteins such as KGF, follistatin, stem cell factor
, collagens and laminins, which support the epidermal stem cells that renew skin throughout life.
Each well contained 2 x [10.sup.5] BMMNCs with 0.1 [micro]g/mL rat granulocyte macrophage colony-stimulating factor (GM-CSF) (Sigma-Aldrich, USA), 5 IU/mL rat stem cell factor
(SCF) (Sigma-Aldrich, USA), 1 IU/mL rat interleukin-3 (IL-3) (Sigma-Aldrich, USA), and 10 U/mL rat erythropoietin (EPO) (Sigma-Aldrich, USA).
They did this by using sophisticated gene sequencing methods to demonstrate a regulatory link between the stem cell factor
Lin28 and the signaling molecule bone morphogenic protein 4 (BMP4).
The newly identified stem cell factor
is BRD4, a protein associated with several cancers and the target of prospective therapies currently in clinical trials.
confirmed the importance of perivascular cells in maintaining the HSC niche through the production of stem cell factor
ALDH3: aldehyde dehydrogenase 3; EDA: ectodysplasin A; EGF: epidermal growth factor; FGF: fibroblast growth factor; IGF: insulin growth factor; IL: interleukin; SHH: sonic hedgehog; SCF: stem cell factor
. Secretome components References ALDH3 activator  EDA  EGF  FGF2  FGF7 [28, 29] FGF10 [29-31] Heparan sulfate [31, 32] IGF1  IL-6  SHH  SCF  Wnt [36-38] TABLE 2: In vivo and in vitro tested oral stem cell lines for salivary gland regeneration.