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A Phase 1 stem cell mobilization study in healthy volunteers showed that BL-8040 as a single agent was safe and well tolerated at all doses tested and resulted in efficient stem cell mobilization and collection.
But all that changed after the stem cell mobilization protocol.
Any compound that interferes with CXCR4 or SDF-1 will promote stem cell mobilization.
Other therapeutic development programs are focused on stem cell mobilization, ALS, cancer, HIV/AIDS, neuropathic pain, nerve regeneration, Parkinson's disease and monogenic diseases.
Our preclinical research has demonstrated that the combination of Imprime PGG and G-CSF enhances the mobilization of stem cells beyond that induced by G-CSF alone and also enhances stem cell mobilization in animals that respond poorly to G-CSF alone," said Daniel Conners, chairman of Biothera.
However, six months after the injections, the researchers found no evidence that the stem cell mobilization factor provided any significant benefit.
Safety and efficacy of healthy volunteer stem cell mobilization with filgrastim G-CSF and mobilized stem cell apheresis: results of a prospective longitudinal 5-year follow-up study.
The company says the 2 Phase III trials will evaluate AMD3100 in a standard stem cell mobilization regimen in non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM) patients undergoing stem cell transplantation.
The CXCL12 / CXCR4 / CXCR7 axis has been shown to play a role in stem cell mobilization, vasculogenesis, tumor growth and metastasis.