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Efficacy and safety of subantimicrobial dose, modified-release doxycycline 40 mg versus doxycycline 100 mg versus placebo for the treatment of inflammatory lesions in moderate and severe acne: A randomized, double-blinded, controlled study.
Subantimicrobial dose of doxycycline has the advantage of being safe because of low plasma concentration (peak concentrations of 0.
Her preferred oral agent is delayed-release doxycycline (Oracea) at the anti-inflammatory but subantimicrobial dose of 40 mg once daily, a dosage that is Food and Drug Administration approved for treatment of rosacea.
8) A subantimicrobial dose of doxycline (SDD) (doxycycline hyclate [Periostat[R]]) has been used to effectively inhibit MMP enzyme mechanisms such as collagenase.