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Essence; the material or necessary component of something.

A matter of substance, as distinguished from a matter of form, with respect to pleadings, affidavits, indictments, and other legal instruments, entails the essential sufficiency, validity, or merits of the instrument, as opposed to its method or style.

West's Encyclopedia of American Law, edition 2. Copyright 2008 The Gale Group, Inc. All rights reserved.

SUBSTANCE, evidence. That which is essential; it is used in opposition to form.
     2. It is a general rule, that on any issue it is sufficient to prove the substance of the issue. For example, in a case where the defendant pleaded payment of the principal sum and all interest due, and it appeared in evidence that a gross sum was paid, not amounting to the full interest, but accepted by the plaintiff as full payment, the proof was held to be sufficient. 2 Str. 690; 1 Phil. Ev. 161.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
References in periodicals archive ?
[1] Ignacio Madrazo et al., "Transplantation of Fetal Substantia Nigra an Adrenal Medulla to the Caudate Nucleus in Two Patients with Parkinson's Disease," New England Journal of Medicine 318 (January 7, 1988), 51; Olle Lindvall et al., cited in Georgina Ferry, "New Cells for Old Brains," New Scientist (March 24, 1988), 54-58; "British Fetal Cell Implants," New York Times (April 19, 1988), 27.
Due to degeneration of substantia nigra and/ or Globus pallidus concentration of dopamine in nigrostriatal system is reduced.
Arzberger, "Microglia activation is related to substantia nigra echogenicity," Journal of Neural Transmission, vol.
When the authors counted the number of TH-positive neurons, the different types of microscopes, various magnification (such as x10, x40, x100, and x200), different sample drawing areas of the substantia nigra, different numbers of specimens of brain glass (such as 3 brain slices or 5 brain slices), different slices of brain tissue thickness (such as cut into 20 [micro]m and 30 [micro]m), and use of diverse anesthetics (such as chloral hydrate, pentobarbital sodium, and urethane) in different studies may contribute to this discrepancy.
The central amygdala projection to the substantia nigra reflects prediction error information in appetitive conditioning.
While portions of globus pallidus and pars reticularis of substantia nigra have relatively higher iron content in healthy individuals, patients of PKAN have excessive amounts of iron accumulated in these nuclei.
Present study intends to investigate the neuro protective potential of polydatin against Parkinson disease, its effects on neuro-motor behavior and dopaminergic neuronal degeneration in striatum and substantia nigra of brain in Parkinson disease using rats as mammalian model.
Parkinson's disease is a degenerative, progressive disorder characterised by the dramatic reduction of nerve cells, particularly dopamine neurons that are involved in movement initiation, in an area of the brain called the substantia nigra.
The disorder is due to a loss of nerve cells in an area deep within the brain called the substantia nigra.
The main hallmark of neuroinflammation in Parkinson's disease is the presence of activated microglia in the substantia nigra of humans [3] and animal models of that disease [4-6].
Parkinson's disease and parkinsonism occur due to deficiency of the neurotransmitter dopamine in the substantia nigra.