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Essence; the material or necessary component of something.

A matter of substance, as distinguished from a matter of form, with respect to pleadings, affidavits, indictments, and other legal instruments, entails the essential sufficiency, validity, or merits of the instrument, as opposed to its method or style.


(Essential nature), noun actuality, basis, body, content, core, drift, essence, essential part, force, gist, heart, hypostasis, idea, import, marrow, material, meaning, pith, principle, purport, reality, res, sense, significance, signification, soul, sum, tenor, vital part


(Material possessions), noun assets, command of money, corpus, estate, fortune, income, means, money, ownership, property, resources, revenue, riches, treasure, wealth, wherewithal
See also: amount, article, body, bulk, capsule, center, composition, connotation, consequence, construction, content, contents, contour, cornerstone, corpus, element, essence, gist, gravamen, import, importance, main point, materiality, meaning, money, object, point, possessions, property, purpose, quantity, reality, shape, significance, signification, spirit, structure, sum, value

SUBSTANCE, evidence. That which is essential; it is used in opposition to form.
     2. It is a general rule, that on any issue it is sufficient to prove the substance of the issue. For example, in a case where the defendant pleaded payment of the principal sum and all interest due, and it appeared in evidence that a gross sum was paid, not amounting to the full interest, but accepted by the plaintiff as full payment, the proof was held to be sufficient. 2 Str. 690; 1 Phil. Ev. 161.

References in periodicals archive ?
com/JNN/A38), the striatum, which receives excitatory stimulus from the cerebral cortex, projects increased inhibitory impulses to the internal segment of globus pallidus and substantia nigra, which in turn decrease impulses sent to the thalamus (Helie, Chakravarthy, & Moustafa, 2013).
Mice was decapitated, the substantia nigra were rapidly removed and dissected on an ice-cold glass plate.
The characteristic motor symptoms appear only when most of the dopaminergic neurons in the substantia nigra have died.
Hence, the degree of Parkinsonism is associated with pathology in the striatum and especially the putamen and the substantia nigra.
We used brain parenchyma sonography, an ultrasound technique, to display the tissue echogenicity of the substantia nigra in 59 patients.
Structures such as the ventricles, the brainstem, tumors and even small areas such as the substantia nigra (SN) can now be clearly identified.
In summary, the primary goal of this study was to evaluate whether disordered hematopoiesis regulation via substantia nigra neuron lesion may induce hematological disorders.
VISIBLE LOSSES Like a time-lapse series of snapshots, repeated imaging of the substantia nigra can both track the disease's progression and monitor the effects of treatment.
1,2) Peduncular hallucinations have been reported in vascular and infective lesions of the thalamus, pars reticulata of the substantia nigra, midbrain, pons, and basal diencephalon, as well as compression of the midbrain.
In Parkinson's disease, cells in the substantia nigra region of the brain are gradually destroyed, leading to a deficiency of the brain chemical dopamine.
Several articles have described MR image findings associated with West Nile virus: hyperintense basal ganglia or thalami on T2-weighted images, enhancement of the leptomeninges or periventricular white matter, and abnormalities of the pons, dentate nuclei, substantia nigra, and red nuclei (5-7).
In normal individuals, cells in a portion of the middle brain, called the substantia nigra, control the production of tyrosine hydroxylase (TH), an enzyme.