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Second, those increased testosterone levels were significantly associated with increased sexual activity, sexual desire, and erectile function (remember, the subjects were all older than 65 years).
Finally, men treated with testosterone demonstrated an improvement in mood and a reduction in depressive symptoms compared with those receiving placebo gel.
The population under study was divided into two groups on basis of levels of Serum Testosterone.
Low Serum Testosterone was found in 34% of the population.
The men treated with placebo also had lower average hemoglobin level changes, compared with those treated with testosterone.
A second trial examined the effect of 12 months of testosterone gel or placebo on bone mineral density in a group of 211 men with average testosterone concentrations less than 275 ng/L (JAMA Intern Med.
There Is no evidence that putting a hypogonadal man on testosterone increases his risk of getting prostate cancer," says Eric Klein, MD, chairman of Cleveland Clinic's Glickman Urological & Kidney Institute.
Klein notes that problems with testosterone occur primarily in men with advanced prostate cancer, "where the molecular apparatus that responds to testosterone is so mutated that minute amounts of testosterone cause the cancer to grow.
Fourth, the target cells for testosterone also age.
Fifth, as a consequence of previous disorders, the testosterone metabolic effects on the male body gradually decline with age.
Testosterone is present in the body in 3 forms: free testosterone, albumin-bound testosterone, and testosterone bound to sex hormone-binding globulin (SHBG).
Testosterone abuse is also linked to withdrawal symptoms once the person stops taking the drug - like fatigue, irritability, loss of appetite, insomnia and decreased libido.