tolerable

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"Diroximel fumarate demonstrated statistically superior Gl tolerability compared to dimethyl fumarate on the EVOLVE-MS-2 study's primary endpoint, as well as a low discontinuation rate of less than 1% due to Gl adverse events.
Under the ongoing accelerated dose-escalation part, the company will assess the safety and tolerability of intratumorally injected AGI-134 as a monotherapy, as well as to determine the maximum tolerated dose and the recommended dose for part two of the study.
In the four clinical studies (ACHIEVE I, ACHIEVE II, UBR-MD-04 and 3110-105-002) supporting the NDA, ubrogepant demonstrated efficacy, safety and tolerability in the acute treatment of migraine among a broad patient population, including those who had an insufficient response to a triptan or those patients in whom triptans were contraindicated, as well as in patients who had moderate to severe CV risk profile.
Once the recommended Phase II dose has been identified, the second part of the study will evaluate the safety and tolerability of birinapant in combination with KEYTRUDA in several cohorts.
Safety and tolerability of Dr Ohhira's OM-X capsules in healthy volunteers.
"The tolerability was rated as 'very good' or 'good' by the investigators for 99% of the subjects, and by 98% of subjects in self-assessment with no statistical differences to placebo," said Barbara Grube, MD, coordinating investigator and lead author of the study.
The tolerability of the different concentrations was assessed after weekly instillations into the urinary bladder for 6 weeks.
In addition, the second pivotal study, like the first one, demonstrated a favourable safety and tolerability profile compared to placebo.
The company said its hepatitis C drug candidate showed positive "proof-of-concept" results, while meeting safety and tolerability goals in an early-stage study.
Although low and moderate doses show a favourable profile, there is concern about the tolerability of higher doses.
(Nasdaq:CHTP), Charlotte, N.C., has initiated enrollment and patient dosing in a multinational, 12-week, double-blind Phase II trial designed to compare the efficacy and tolerability of CH-1504 against methotrexate (MTX) in rheumatoid arthritis (RA) patients.