The website's focus was going to be about arginase deficiency, as well as urea cycle
With a portfolio of products for the treatment of Phenylketonuria, Gaucher Disease, Niemann Pick Type C, Hereditary Tyrosinemia Type 1, Urea Cycle
Disorders and others, Dipharma SA works to provide solutions for people affected by inborn metabolic diseases at an affordable cost and with a global reach.
For example, alterations in the levels of glutamine synthetase and urea cycle
enzymes and intermediates have been observed in AD brain.
Nitrogen scavengers were not initiated at this time since there were no abnormalities in the rest of the urea cycle
panel, ammonia began to trend down, and her mental status subsequently improved.
Lichter-Konecki et al., "Cross-sectional multicenter study of patients with urea cycle
disorders in the United States," Molecular Genetics and Metabolism, vol.
These range from orphan indications, such as rare inborn metabolic diseases including urea cycle
disorders (UCD) to large indications such as acute-on-chronic liver failure (ACLF), and nonalcoholic steato-hepatits (NASH)/fibrosis.
Additionally, if ammonia is not removed from the Urea Cycle
, the body uses another important substance called BH4 to neutralize it.
Auxiliary liver transplant is proposed for liver-based metabolic defects that do not structurally damage the liver such as CNS I, urea cycle
defects, and familial hypercholesterolaemia.
Her clinical and research interests include inborn errors of metabolism, especially phenylketonuria, urea cycle
disorders, and CNS complications of these disorders.
Citrin deficiency caused by SLC25A13 mutation is another disorder of the urea cycle
* ArgiFlow to help maintain the body's immune system and growth hormone levels, and to promote the urea cycle
in the removal of ammonia from the body;
Cytonet, Weinheim, Germany announced in January that the European Medicines Agency (EMA) has validated its Marketing Authorization Application (MAA) seeking approval of its liver cell therapy for the treatment of Urea Cycle
Disorders (UCD) in children.