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Related to variola virus: variola major virus, varicella, varicella zoster virus, chicken pox, vaccinia virus
See: disease
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it seems highly likely that a similar range of strains of variola virus of different virulence for man occurred in countries in which smallpox had been endemic for years.
Natural infection with variola virus occurred following transmission of infective aerosolized droplets on the oropharyngeal or respiratory mucosa.
A smallpox diagnostic panel compiled by Inger Damon s laboratory at the CDC included 12 different variola virus isolates (VAR), 13 different strains and isolates of camelpox, cowpox (CPV), ectromelia, herpes, monkeypox, Staphylococcus aureus, vaccinia (VV), and varicella-zoster viruses (VZV).
Adefovir dipivoxil is probably not effective, although theoretically it can inhibit replication of variola virus DNA.
Since transmission of smallpox occurs through inhalation of airborne variola virus, usually droplets expressed from the oral, nasal, or pharyngeal mucosa of an infected person, non-invasive anti-viral treatment alternatives with proven agents (cidofovir) are needed.
Smallpox is caused by variola virus (genus Orthopoxvirus).
Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family.
Moreover, in light of the new WHO safety regulations restricting work with variola virus DNA [greater than or equal to]500 by in length (15), the availability of an MPV-derived, mutagenized plasmid provides a practical and compatible positive control for VAR.
Dennis Hruby, will be presenting information regarding the company's progress in developing its lead drug candidate, ST-246, to the WHO Advisory Committee on Variola Virus Research on November 28, 2007 in Geneva, Switzerland.
Viruses in the family Poxviridae, genus Orthopoxvirus, consist of numerous pathogens known to infect humans, including variola virus (VARV), monkeypox virus (MPXV), cowpox virus (CPXV), and vaccinia virus (VACV).
Sledgehammer smallpox, caused by the variola virus, develops a non-typical rash and patients succumb to the disease fairly rapidly, which further increases the urgency to find a cure.