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Blood was collected in 50 mM EDTA at pH 8.0 to prevent coagulation, and genomic DNA was extracted from white blood corpuscles. DNA extraction was carried out according to the procedure described by Xiong and Deng (1999).
The point of the sting turns red because tiny blood vessels expand, through which swarms of white blood corpuscles flow.
The Ministry of Health, Labor and Welfare has instructed Ciba-Geigy Japan Ltd., a wholly owned subsidiary of Novartis Pharma Japan K.K., to revise its product information description to include side effects such as the risk of developing serious skin problems and pancytopenia, or a decrease in red and white blood corpuscles as well as plasma, the officials said.